Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy

BACKGROUND. Fatigue is a common and often severe problem in cancer patients undergoing chemotherapy. The authors postulated that physical activity tra ining can reduce the intensity of fatigue in this group of patients. METHODS, A group of cancer patients receiving high dose chemotherapy follow ed by autologous peripheral blood stem cell transplantation (training group ; n = 27) followed an exercise program during hospitalization. The program was comprised of biking on an ergometer in the supine position following an interval training pattern for 30 minutes daily. Patients in the control gr oup (n = 32) did not train. Psychologic distress was assessed at hospital a dmission and discharge with the Profile of Mood States and Symptom Check Li st 90. RESULTS. By the time of hospital discharge, fatigue and somatic complaints had increased significantly in the control group (P for both < 0.01) but no t in the training group. Furthermore, by the time of hospital discharge, th e training group had a significant improvement in several scores of psychol ogic distress (obsessive-compulsive traits, fear, interpersonal sensitivity , and phobic anxiety) (P Value for all scores < 0.05); this outcome was not observed in the control group. CONCLUSIONS. The current study found that aerobic exercise can reduce fatig ue and improve psychologic distress in cancer patients undergoing chemother apy. Cancer 1999;85:2273-7, (C) 1999 American Cancer Society.