Use of hydroxyurea in psoriasis

Authors
Citation
Ch. Smith, Use of hydroxyurea in psoriasis, CLIN EXP D, 24(1), 1999, pp. 2-6
Citations number
33
Categorie Soggetti
Dermatology
Journal title
CLINICAL AND EXPERIMENTAL DERMATOLOGY
ISSN journal
03076938 → ACNP
Volume
24
Issue
1
Year of publication
1999
Pages
2 - 6
Database
ISI
SICI code
0307-6938(199901)24:1<2:UOHIP>2.0.ZU;2-V
Abstract
Hydroxyurea is an effective treatment in chronic plaque psoriasis that is r elatively simple to prescribe, Dose-related bone marrow toxicity is the pri ncipal side-effect of therapy although clinically significant complications are few provided that blood counts are monitored carefully In contrast wit h many other second-line agents, renal and liver disease do not necessarily preclude treatment, and there are few drug interactions likely to be of cl inical relevance in dermatology. Recent studies on the use of hydroxyurea f or sickle cell disease may provide more information on predicting the maxim al tolerated dose and potential hazards of long-term therapy in nonmalignan t disease and perhaps revive interest in the drug's use in dermatology.