Cutaneous granulomatous lesions in common variable immunodeficiency: Complete resolution after intravenous immunoglobulins

A 64-year-old man with common variable immunodeficiency developed a persist ent papulonodular ulcerative eruption on the right leg. Histopathological e xamination disclosed a chronic inflammatory infiltrate with central necrosi s and palisading granuloma. Repeated microbiological (bacteriological, myco logical and mycobacteriological) studies failed to isolate any microorganis m. After treatment with intravenous immunoglobulins, a progressive resoluti on of the skin lesions was observed with a complete clearing after 10 month s. Clinicopathological features and therapeutic approaches of sterile granu lomatous lesions associated with primary immunodeficiencies are reviewed.