R. Kuroki et al., Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: Improvement by diet control, DERMATOLOGY, 198(2), 1999, pp. 164-166
We report on a 27-year-old man with acanthosis nigricans (AN) associated wi
th severe obesity, insulin resistance and hypothyroidism, A very low-calory
diet treatment decreased his weight and then ameliorated the insulin-resis
tant state. These effects were followed by remarkable improvement of the AN
prior to the correction of the hypothyroidism, This confirms that AN may b
e mainly attributed to insulin resistance rather than hypothyroidism per se
.