GLIPIZIDE-GITS DOES NOT INCREASE THE HYPOGLYCEMIC EFFECT OF MILD EXERCISE DURING FASTING IN NIDDM

OBJECTIVE - This study compared the effect of mild exercise while fast ing on plasma glucose concentrations in subjects with NIDDM treated wi th extended-release glipizide and subjects not taking an oral hypoglyc emic agent. RESEARCH DESIGN AND METHODS - Twenty-five moderately obese subjects with NIDDM were randomized to treatment with extended-releas e glipizide or placebo. After 9 weeks of treatment, they fasted overni ght, took their study drug, omitted breakfast, and exercised on a trea dmill for 90 min. Glucose, insulin, and C-peptide concentrations were measured before, during, and after exercise. RESULTS - On the fasting- exercise day, fasting glucose concentrations were lower (153 vs. 241 m g/dl, P < 0.01) and insulin and C-peptide concentrations higher in the extended-release glipizide group. The decrement of glucose from the f asting baseline was modest and equivalent in the two groups: 17 vs. 21 mg/dl at the end of exercise and 28 vs. 27 mg/dl after 2 h of recover y. No subject had hypoglycemic symptoms. CONCLUSIONS - Chronic use of extended-release glipizide does not enhance the hypoglycemic effect of fasting plus mild exercise for people with NIDDM. Routine lifestyle t reatments for NIDDM may be continued during ongoing use of this agent.