Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparisonof MIC (PERB11) and C4

Citation
Sk. Cattley et al., Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparisonof MIC (PERB11) and C4, EUR J IMM, 26(2-3), 1999, pp. 233-238
Citations number
23
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOGENETICS
ISSN journal
09607420 → ACNP
Volume
26
Issue
2-3
Year of publication
1999
Pages
233 - 238
Database
ISI
SICI code
0960-7420(199904/06)26:2-3<233:PAOPM(>2.0.ZU;2-8
Abstract
Duplication of segments within the MHC has led to numerous multicopy famili es such as class I, class II, C4 and MIC (PERB11). Different copy numbers b etween haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanz ee. By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang- utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess M ICD (PERB11.4) and/or MICE (PERB11.5 rather than MICA. (PERB11.1). These fi ndings indicate that the primate MHC is more plastic than has been apprecia ted.