Influence of microwave irradiation on kinetic parameters of single Ca2+-activated K+ channels

Using the patch voltage-clamp method, the influence of millimeter microwave s (42.25 GHz) on kinetic parameters of single Ca2+-activated K+ channels in cultured kidney cells Vero was studied. It was found that exposure to the field of non-thermal power (about 100 mu W/cm(2)) for 20-30 min greatly mod ifies both open and closed times at the channel activity. Therewith, the de pendencies of these parameters on internal Ca2+ and membrane voltage are gr eatly deteriorated. The data suggest that the field alters both cooperativi ty and binding characteristics of the channel activation by internal Ca2+.