Deep vein thrombosis is not associated with the P/S186 polymorphism of histidine rich glycoprotein

Background: In several studies, higher plasma levels of histidine-rich glyc oprotein (HRG) have been observed in patients with venous thrombosis than i n healthy subjects. Apart from environmental factors, such as the use of or al contraceptives, the plasma HRG levels are mainly determined genetically. The most important genetic determinant is P/S186 polymorphisms in exon 5 o f the HRG gene which is associated with 40% higher HRG levels. In this stud y we investigated the relationship between the HRG P/S 186 polymorphism and venous thrombosis. Methods and Results DNA was available from 466 patients and 471 controls of the Leiden Thrombophilia Study (LETS), a population-based case-control stu dy on venous thrombosis. Both in patients and controls, the genotype distri bution of the P/S186 polymorphism was not different from that predicted by the Hardy-Weinberg equilibrium. No association between the genotypes of the P/S186 polymorphism and deep-vein thrombosis was found (PS 186 genotype: O R: 0.97 (CI:0.24,1.70); SS 186 genotype: OR: 1.12 (CI:0.21,2.04), PP 186 is the reference category). Conclusion: The results of this study suggest that the HRG P/S 186 polymorp hism is not associated with first venous thrombotic events.