On-line coupled liquid chromatography - Gas chromatography in the analysisof process samples

Normal phase liquid chromatography-gas chromatography was used with on-colu mn interfacing and partially concurrent solvent evaporation in the analysis of process samples. Samples were taken from reaction mixtures, where the s olvent was toluene, The analytes were oxygenated compounds: methyl isobutyr ate, methyl methacrylate, methyl alpha-formyl isobutyrate, and methyl beta- formyl isobutyrate. The analytes were transferred from LC to GC using back- flush with a solvent mixture of pentane and diethyl ether. Linearity, repea tability, and transfer efficiency were determined for the method, The metho d was applied in the determination of the analytes of two different process samples. The results were in good agreement with results obtained by the g as chromatographic method currently in use for the analysis of the process samples.