Human CD4(+) T cell differentiation and effector function - Implications for autoimmunity

Human CD4(+) memory T cells progress through stages of postthymic different iation that have been characterized by distinct phenotypes. We have investi gated the factors regulating cytokine production, and the correlation betwe en phenotype and effector function in normal and autoimmune individuals. Th ese studies suggest that antigen-induced proliferation in the periphery dri ves CD4(+) T cells through successive stages of differentiation that culmin ate in optimal effector function and resistance to external modulatory infl uences. Moreover, these studies support the concept that in autoimmune indi viduals, the chronic accumulation of differentiated proinflammatory T cells perpetuate the inflammatory response resulting in aggressive disease.