Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-beta 1, for atopy and asthma

Authors
Rosenwasser, LJ
Citation
Lj. Rosenwasser, Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-beta 1, for atopy and asthma, INT A AL IM, 118(2-4), 1999, pp. 268-270
Citations number
14
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
ISSN journal
10182438 → ACNP
Volume
118
Issue
2-4
Year of publication
1999
Pages
268 - 270
Database
ISI
SICI code
1018-2438(199902/04)118:2-4<268:PPITCG>2.0.ZU;2-3
Abstract
This paper will review genetic variations in the structure of three importa nt candidate genes with varying effects in atopy and asthma that may have s ignificant overall susceptibility associations in relation to the developme nt of atopy and asthma. The three cytokine genes involved are interleukin ( IL)-4, IL-9 and transforming growth factor beta 1, and the nature of the po lymorphisms may be related to significantly higher outputs of these cytokin es in atopy and asthma.