CD44v6 expression is an independent prognostic factor in node-negative FIGO stage IB cervical carcinoma

Adhesion molecules such as CD44 play an important role in the metastatic ca scade by mediating tumor cell interaction with the endothelium and the sube ndothelial matrix. As a so-called "lymphocyte homing receptor," CD44 is phy siologically involved in migration of circulating lymphocytes to lymphatic tissue. In the present study, we investigated the expression of CD44v3 and v6 in 237 patients with stage IB, NO cervical carcinoma by means of immunoh istochemistry. These results were correlated with the GOG score and other p rognostic variables. Median follow-up was 82.6 months (39-110 months). Thir ty-nine patients recurred and 35 died from disease within the observation p eriod. In univariate analysis, the GOG score, histologic subtype, and CD44v 6 expression were statistically significant predictors for poor overall sur vival (OS). In multivariate (Cox regression) analysis, the GOG score (< 40 vs. 40-120, RR: 1.37 (95% CI: 1.10-1.71); 40-120 vs. > 120, RR: 2.23 (95% C I: 1.28-3.88); P = 0.004), histologic subtype (adenosquamous carcinomas) (R R: 4.56 (95% CI: 1.49-13.92), P = 0.007) and CD44v6 expression (RR: 2.42 (9 5% CI: 1.14-5.10), P = 0.021) were independent predictors for poor OS. The expression of CD44v3 did not correlate with prognosis. Furthermore we found a strong correlation between CD44v6 expression and lympho-vascular space i nvasion (LVSI) (chi(2) = 17.01, P = 0.0001). Tumor expansion into the loco- regional lymphatic system is the preferred way of tumor spread in cervical carcinoma. The strong correlation of CD44v6 with LVSI produces a significan t degree of suspicion that cervical carcinoma cells expressing CD44v6 could , by mimicking lymphocytes, exploit their pathways.