To assess the importance of intercenter variations when measuring magnetiza
tion transfer ratio (MTR) in the brain, six European centers measured MTR i
n normal white matter. MTR ranged from 9 to 51 percent units (25 sequences)
, The effective flip angle of the saturating pulse divided by the pulse rep
etition time (ENRsat degrees/msec) was a good predictor of MTR (MTR = 3.25
ENRsat). (C) 1999 Wiley-Liss, Inc.