R. Wyttenbach et al., Detection of acute myocardial ischemia using first-pass dynamics of MnDPDPon inversion recovery echoplanar imaging, J MAGN R I, 9(2), 1999, pp. 209-214
Previous studies used manganese N,N'-bis-(pyridoxal 5-phosphate)ethylenedia
mine-N,N'-diacetic acid (MnDPDP) to detect myocardial ischemia at a dose of
0.4 mmol/kg with spin echo imaging. The purpose of this study was to detec
t acute myocardial ischemia using MnDPDP at a dose range near that approved
for hepatobiliary imaging (0.005 mmol/kg) in conjunction with inversion re
covery echoplanar imaging (nr. EPI), Regional ischemia was produced in 26 r
ats by occluding the left coronary artery for 20-30 minutes before imaging.
Consecutive 32 IR EP images (inversion time [TI]/TR/TE 700/2000/10 msec) w
ere obtained to monitor the first pass of MnDPDP at four incremental doses
(0.005, 0.01, 0.02, or 0.04 mmol/kg, n = 6-8), MnDPDP produced dose-depende
nt enhancement of left ventricular blood and normal myocardium, but not isc
hemic myocardium, Quantitative analysis revealed a difference in signal int
ensities (P < 0.05) between normal and ischemic myocardium at the time of p
eak enhancement in all groups. However, differential enhancement between no
rmal and ischemic myocardium produced clear visual delineation of the ische
mic region only at doses greater than or equal to 0.01 mmol/kg. In conclusi
on, acute myocardial ischemia can be detected with IR EPI using doses close
to the clinically approved dose of MnDPDP. J, Magn, Reson, Imaging 1999:9:
209-214, (C) 1999 Wiley-Liss, Inc.