Mangafodipir trisodium: Effects on T2- and T1-weighted MR cholangiography

The purpose of this study was to determine the effects of mangafodipir tris odium on heavily T1-weighted magnetic resonance cholangiography (MRC) image s and on functional T1-weighted MRC, Pre- and post-mangafodipir trisodium h eavily T2-weighted MRC and fat-suppressed T1-weighted three-dimensional (3D ) gradient-echo MRC images were obtained in a patient with a prior cholecys tectomy and a long cystic duct remnant that had apparent biliary stasis, Mu ltiplanar reconstructed images were created. The precontrast T2-weighted MR C showed a long cystic duct remnant and a normal common bile duct (CBD), Th e postcontrast T2-weighted MRC showed loss of CBD signal, but persistent si gnal in the cystic duct remnant due to biliary stasis, Post-mangafodipir T1 -welghted 3D gradient-echo images showed the main right and left hepatic du cts, but the cystic duct was not depicted, Conventional T2-welghted MRC seq uences should not be obtained after administering mangafodipir trisodium be cause this contrast agent decreases the T2 and therefore the signal intensi ty of bile within normally functioning bile ducts. Functional MRC images ca n be acquired by using a post-mangafodipir T1-weighted technique, J. Magn. Reson. Imaging 1999; 9:366-368, (C) 1999 Wiley-Liss, Inc.