On the structural stability of a small bioactive peptide of potential use in biotechnology

Authors
Di Maro, D Scarselli, M Bernini, A Cresti, S Rossolini, GM Lozzi, L Neri, P Niccolai, N
Citation
D. Di Maro et al., On the structural stability of a small bioactive peptide of potential use in biotechnology, J BIO STRUC, 16(5), 1999, pp. 1053-1059
Citations number
18
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN journal
07391102 → ACNP
Volume
16
Issue
5
Year of publication
1999
Pages
1053 - 1059
Database
ISI
SICI code
0739-1102(199904)16:5<1053:OTSSOA>2.0.ZU;2-E
Abstract
A tridecapeptide with the sequence CCEICCNPACFGC has been synthesized to re produce the active moiety of a heat stable enterotoxin from Vibrio cholerae . The proton NMR analysis indicates, for the active synthetic fragment, a r igid secondary structure stabilised by three disulfide bridges. Such a rigi d peptide, suitably detoxified and activated, could be a good candidate to be used as a carrier for linear bioactive peptides or other functional grou ps.