Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum

Cucurbitacin B, isocucurbitacin B, dihydrocucurbitacin B, cucurbitacin E, d ihydrocucurbitacin E, isocucurbitacin D, dihydroisocucurbitacin D, cucurbit acin I, dihydrocucurbitacin I, cucurbitacin Q1, and dihydrocucurbitacin Q1 were identified for the first time as constituents of Cucumis prophetarum L . Cucurbitacin B, cucurbitacin O, cucurbitacin P, cucurbitacin Q1, dihydroc ucurbitacin Q1, isocucurbitacin E, and dihydroisocucurbitacin E also were i dentified as constituents of C. prophetarum Jusl. ssp. Dissectus. Isocucurb itacin E and dihydroisocucurbitacin E were isolated for the first time in n ature. The chemical structures were determined with extensive spectroscopic analysis including 2D NMR, H-1 NMR, C-13 NMR, correlated spectroscopy (COS Y), heteronuclear chemical shift correlation (HETCOR), attached proton test (APT), and distortionless enhancement by polarization transfer (DEPT).