THE SEARCH FOR DISEASE-MODIFYING TREATMENT FOR ALZHEIMERS-DISEASE

As a result of advances in the understanding of neurodegenerative mech anisms in Alzheimer's disease, several strategies for the development of disease-modifying treatment are being investigated. Nerve growth fa ctor and other neurotrophins may improve neuronal survival, although t argeted delivery remains an obstacle. Modulation of protein processing has the potential to decrease the formation of plaques and tangles. P harmacologic reduction of oxidative stress and destructive inflammatio n may slow the rate of neurodegeneration. Continued research into basi c mechanisms, along with therapeutic trials of promising drugs, are im proving the likelihood that it will soon be possible to slow the progr ession of this disease.