Progressive development of diffuse liver hemangiomatosis

Diffuse liver hemangiomatosis is extremely rare, The etiology and natural h istory of the disease are unknown. It is also unclear whether tumor growth is induced or modulated by drug therapy. Tumor recurrence after ablative th erapy has not been described in patients with diffuse liver hemangiomatosis . Diffuse hemangiomatosis of the left hepatic lobe was suspected in a 35-ye ar-old woman by ultrasonography, CT and hepatic arteriography, and confirme d by laparotomy and biopsies. The patient denied any drug or estrogen use. The tumor was removed by left hepatectomy. Two and six years later, the pat ient was again hospitalized with progressive tumor growth into the right he patic lobe, Although diffuse liver hemangiomatosis is a rare disease, its d iagnosis should be considered in patients with progressive tumor growth in one or both hepatic lobes, The absence of drug intake or estrogen use does not exclude the diagnosis.