Polycyclic N-heterocyclic compounds. 50. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]-imidazo[2,1-f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno-[2,3-h]pyrimido[2,1-f][1,6]naphthyridines and their precursor
K. Sasaki et al., Polycyclic N-heterocyclic compounds. 50. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]-imidazo[2,1-f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno-[2,3-h]pyrimido[2,1-f][1,6]naphthyridines and their precursor, J HETERO CH, 36(2), 1999, pp. 461-465
Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3-h][1,6]naphthyridines
were prepared by the reaction of 5-chloro-1,2-dihydrothieno[2,3-h] [1,6]nap
hthyridine derivatives with some aminoalcohols in the presence of base. The
se derivatives were cyclized to the corresponding imidazo or pyrimido deriv
atives. The bronchodilatory activity of these compounds was evaluated on th
e basis of their relaxation activity to tracheal contraction induced by car
bamylcholine chloride as a primary in vitro assays. Effect of some naphthyr
idines on carbamylcholine chloride-induced contractions of trachea in the p
resence or absence of milrinone or 4-(3-butoxy-4-methoxyphenyl)imidazolidin
-2-one, which is inhibitor of phosphodiesterase III or TV, were also evalua
ted.