Polycyclic N-heterocyclic compounds. 50. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]-imidazo[2,1-f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno-[2,3-h]pyrimido[2,1-f][1,6]naphthyridines and their precursor

Citation
K. Sasaki et al., Polycyclic N-heterocyclic compounds. 50. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]-imidazo[2,1-f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno-[2,3-h]pyrimido[2,1-f][1,6]naphthyridines and their precursor, J HETERO CH, 36(2), 1999, pp. 461-465
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
2
Year of publication
1999
Pages
461 - 465
Database
ISI
SICI code
0022-152X(199903/04)36:2<461:PNC5SA>2.0.ZU;2-V
Abstract
Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3-h][1,6]naphthyridines were prepared by the reaction of 5-chloro-1,2-dihydrothieno[2,3-h] [1,6]nap hthyridine derivatives with some aminoalcohols in the presence of base. The se derivatives were cyclized to the corresponding imidazo or pyrimido deriv atives. The bronchodilatory activity of these compounds was evaluated on th e basis of their relaxation activity to tracheal contraction induced by car bamylcholine chloride as a primary in vitro assays. Effect of some naphthyr idines on carbamylcholine chloride-induced contractions of trachea in the p resence or absence of milrinone or 4-(3-butoxy-4-methoxyphenyl)imidazolidin -2-one, which is inhibitor of phosphodiesterase III or TV, were also evalua ted.