Tritium labeling of 7-isopropoxyisoflavone

Authors
Otvos, F Toth, G Szatmari, I Levai, F
Citation
F. Otvos et al., Tritium labeling of 7-isopropoxyisoflavone, J LABEL C R, 42(5), 1999, pp. 497-503
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
5
Year of publication
1999
Pages
497 - 503
Database
ISI
SICI code
0362-4803(199905)42:5<497:TLO7>2.0.ZU;2-7
Abstract
Catalytic tritiodehalogenation of 8-bromoipriflavone and 6,8-dibromoiprifla vone resulted in [8-H-3]ipriflavone (3) and [6,8-H-3(2)]ipriflavone (7) wit h specific activities of 1.08 TBq/mmol (29.2 Ci/mmol) and 1.94 TBq/mmol (52 .4 Ci/mmol), respectively. 8-Bromoipriflavone was synthesized by direct bro mination of ipriflavone, while 6,8-dibromoipriflavone was formed by isoprop ylation of the phenolic OH group of 6,8-dibromo-7-hydroxyisoflavone which i tself was prepared from 7-hydroxyisoflavone and elemental bromine.