The prevalence of hepatitis B surface antigen (HBsAg) was determined in a c
ommunity-based, cross-sectional, age-stratified sample of children from 0 t
o 6 years of age (n = 2,299) from the Eastern Cape Province of South Africa
. The purpose of the study was to investigate the epidemiology and the age
of acquisition of hepatitis B virus (HBV) infection in children, thus provi
ding a preimmunization baseline measure of this infection in the population
targeted for HBV immunization in South Africa. Overall, 10.4% (95% CI, 9.2
-11.7) of the children tested were HBsAg-positive. There was a high rate of
positivity in the 0-6- and 7-12-month age groups at 8.1% (95% CI, 5.5-11.7
) and 8.9% (95% CI, 6.1-12.7), respectively, suggesting a higher rate of ea
rly acquisition of this infection than previously reported in South Africa.
The proportion of HBsAg-positive children increased significantly with inc
reasing age (chi(trend)(2)= 5.9, df = 1, P=0.02), reaching 15.7% in the 61-
72-month age group. This is the highest rate of HBV infection reported in c
ommunity-based children from South Africa, indicating a significant burden
of this infection. The difference in HBsAg prevalence between urban and rur
al children was not statistically significant (chi(2) = 0.32, df = 1, P= 0.
57). There was also no difference in positivity between males (10.5%; 95% C
I, 8.7-12.5) and females (9.8%; 95% CI, 8.1-11.7), (chi(2) = 0.006, df = 1,
P= 0.94). This study provides the most recent preimmunization, community-b
ased baseline investigation of the epidemiology of HBV infection in childre
n targeted for universal immunization in South Africa. J. Med. Virol. 58:11
1-115, 1999. (C) 1999 Wiley-Liss, Inc.