Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine

Authors
Dixon, DJ Ley, SV Gracza, T Szolcsanyi, P
Citation
Dj. Dixon et al., Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine, J CHEM S P1, (8), 1999, pp. 839-841
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
8
Year of publication
1999
Pages
839 - 841
Database
ISI
SICI code
0300-922X(19990421):8<839:TSOTPA>2.0.ZU;2-1
Abstract
The first total synthesis of erythroskyrine, a polyenoyl-tetramic acid myco toxin and principal pigment of Penicillium Islandicum Sopp., is described u sing a palladium(II) catalysed oxycarbonylation to create the furan-derived bicyclic portion 3 and the phosphonate ester 5 to furnish both the polyeno yl chain and the N-methyl (S)-valine derived tetramic acid terminus.