Ja. Hernandez et al., Primary gastrointestinal lymphomas in HIV-patients: report of 15 cases from a series of 76 patients with HIV related non-Hodgkin's lymphoma, MED CLIN, 112(6), 1999, pp. 222-224
BACKGROUND: To analyze the main clinical and biological data and the respon
se to therapy in 15 patients with primary gastrointestinal lymphoma (PGIL)
from a series of 76 patients with HIV related non-Hodgkin's lymphoma (NHL)
diagnosed in a single institution in a 13 years period.
PATIENTS AND METHODS: The main clinical, biological and evolutive data were
recorded. Pathologic diagnosis of PGIL was made according to the REAL clas
sification. Clinical stage was determined by the Ann Arbor system modified
by Rohatiner et al. Response to therapy as well as overall survival (OS) we
re studied. Results were compared with non-PGIL HIV-related NHL patients.
RESULTS: Mean age of the series was 38 years. Thirteen patients were male,
and 8 intravenous drug abusers. Then had bad performance status (ECOG 2-4)
and 11 B symptoms. All patients had a high grade malignant PGIL and the loc
alization was gastric in 10 cases. The most frequent symptoms were abdomina
l pain (11 cases), gastrointestinal bleeding (4) and dysphagia (3). Ten pat
ients had advanced stages (IIE2-IV). The median CD4 cell count was lower in
PGIL patients (92 x 10(6)/l vs 148 x 10(6)/l; p < 0.05). Thirteen patients
received intensive chemotherapy with CHOP regimen (in 5 surgical procedure
s were previously made). Complete response (CR) was obtained in 4 patients
(31%) and 1 of them relapsed. Median OS was 10 months vs 16 months non-PGIL
HIV-related lymphoma patients (p < 0.05).
CONCLUSIONS: PGIL in HIV patients often presented advanced stages and high
grade of malignancy. The most common localization is the stomach, and these
patients usually have bad performance status and a low CD4 lymphocyte coun
t. Response to therapy is poor. In our series OS was worse in PGIL patients
than in the rest of HIV-related NHL, possibly due to the high degree of im
munosuppression in the formers.