Out patient blood pressure and left ventricular hypertrophy in untreated hypertensive patients

Citation
Jm. Pascual et al., Out patient blood pressure and left ventricular hypertrophy in untreated hypertensive patients, MED CLIN, 112(5), 1999, pp. 166-170
Citations number
41
Categorie Soggetti
General & Internal Medicine
Journal title
MEDICINA CLINICA
ISSN journal
00257753 → ACNP
Volume
112
Issue
5
Year of publication
1999
Pages
166 - 170
Database
ISI
SICI code
0025-7753(19990213)112:5<166:OPBPAL>2.0.ZU;2-Y
Abstract
BACKGROUND: The study was designed to evaluate blood pressure (BP) values r elated to left ventricular hypertrophy (LVH) in a group of never treated mi ddle-aged hypertensive subjects. PATIENTS AND METHOD: Non-invasive ambulatory blood pressure monitoring (ABP M) and echocardiography were performed in 149 hypertensive patients (25-50 years-old) with diastolic blood pressure (DBP) 90-114 mmHg. LVH was conside red when left ventricular mass (LVM) was > 134 g/m(2) in males and > 110 g/ m(2) in females. RESULTS: 43% of patients had LVH. Patients with LVH had higher clinic and a mbulatory BP values. The greatest diferences were in mean 24 h SBP (p = 0.0 01) and in 24 h DBP (p = 0.006). With respect to LVH, there were no differe nces between dippers and non-dippers, males or females, and circadian or BP variability. LVM was positively correlated with clinical DBP (p = 0.24), 2 4 h SEP (p = 0.41), pulse pressure (PP) (p = 0.36) and absolute BP variabil ity (p = 0.23), Multiple regression analysis confirmed that 24 h SEP and se x where positively associated with LVH independent of others factors. The e xistence of 24 h SEP > 150 mmHg dramatically increased the risk of LVH (odd s ratio [OR] = 9.2; CI 95%: 2.8-29.3; p = 0.002). CONCLUSIONS: The present study indicates that in never treated middle-aged essential hypertensive patients the principal factor related to the presenc e of LVH is the value of systolic blood pressure throughout a 24 h period.