RETENTION AND ENANTIOSELECTIVITY PROPERTIES OF BETA-CYCLODEXTRIN POLYMERS AND DERIVATIVES ON POROUS SILICA FOR REVERSE-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS

Chiral stationary phases (CSP) based on porous silica coated with beta -cyclodextrin polymer and methylated or acetylated derivatives have be en prepared. Their enantiomer separation capability was tested and com pared under reversed-phase mode elution conditions. Noticeable changes in retention properties were noted and in many cases a reverse enanti oselectivity was evidenced, as a consequence of a strong modification of the energy, geometry and number of points of contact between solute s and stationary phase sites of molecular recognition.