The interrelationships between proteasomes and viral gene products are very
complex. 20S proteasomes associate with a number of viral mRNAs which are
cleaved by proteasome's associated endonuclease activity. In addition prote
asome's endopeptidase activities are involved in the presentation of viral
antigens. Viral proteins of different origin associate with the 20S and 26S
complexes and interfere with their enzymatic activities. A major part of t
his review deals with the interactions between 20S proteasomes and the gene
products of the human immunodeficiency virus (HIV) which has been studied
in detail by our group.