Relationships between proteasomes and viral gene products

Citation
As. Jarrousse et al., Relationships between proteasomes and viral gene products, MOL BIOL RP, 26(1-2), 1999, pp. 113-117
Citations number
54
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY REPORTS
ISSN journal
03014851 → ACNP
Volume
26
Issue
1-2
Year of publication
1999
Pages
113 - 117
Database
ISI
SICI code
0301-4851(199904)26:1-2<113:RBPAVG>2.0.ZU;2-O
Abstract
The interrelationships between proteasomes and viral gene products are very complex. 20S proteasomes associate with a number of viral mRNAs which are cleaved by proteasome's associated endonuclease activity. In addition prote asome's endopeptidase activities are involved in the presentation of viral antigens. Viral proteins of different origin associate with the 20S and 26S complexes and interfere with their enzymatic activities. A major part of t his review deals with the interactions between 20S proteasomes and the gene products of the human immunodeficiency virus (HIV) which has been studied in detail by our group.