Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates

Authors
Cheruvallath, ZS Wheeler, PD Cole, DL Ravikumar, VT
Citation
Zs. Cheruvallath et al., Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates, NUCLEOS NUC, 18(3), 1999, pp. 485-492
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
3
Year of publication
1999
Pages
485 - 492
Database
ISI
SICI code
0732-8311(1999)18:3<485:UOPD(I>2.0.ZU;2-7
Abstract
Investigations into the use of phenylacetyl disulfide (PADS) as an efficien t sulfur transfer agent in the solid phase synthesis of oligodeoxyribonucle otide phosphorothioates showed that under suitable solvent conditions, this relatively inexpensive reagent rapidly and efficiently sulfurizes internuc leotide phosphite linkages.