Vitamin E suppresses oxidative stress and glomerulosclerosis in rat remnant kidney

Previous studies have shown that reduction of renal mass in the rat remnant kidney model induces overproduction of transforming growth factor beta 1 ( TGF beta 1). We investigated whether an antioxidant, vitamin E, administere d before the renal mass reduction, could prevent oxidative stress, reduce t he overproduction of TGF beta 1, and mitigate against the subsequent glomer ulosclerosis. Our results revealed that the oxidative stress, as measured b y the change in plasma malondialdehyde, is significantly reduced by prior v itamin E dietary supplementation. Finally, our data show that dietary vitam in E supplementation ameliorates the rise in TGF beta 1 secondary to renal mass reduction and inhibits the glomerular sclerosis of the remnant kidney over the time course of this experiment.