Techneitum-99m tetrofosmin single photon emission computed tomography: sensitive for diagnosing coronary artery disease, specific for diagnosing reversible perfusion defects
M. Hanje et al., Techneitum-99m tetrofosmin single photon emission computed tomography: sensitive for diagnosing coronary artery disease, specific for diagnosing reversible perfusion defects, PERFUSION, 12(2), 1999, pp. 44
Background: Sensitivity for the overall detection of coronary artery diseas
e Thallium-201 is approximately 85%, There is, thus, room for a more sensit
ive approach.
Aim: The purpose of this study was to evaluate the clinical value of visual
analysis of Tc-99m tetrofosmin single photon emission computed tomography
(SPECT) for the assessment of the presence, localization and extent of coro
nary artery disease (CAD),
Methods: Exercise myocardial perfusion imaging was prospectively performed
in 85 patients. The results were compared to coronary angiographic findings
which served as the gold standard,
Results: Angiographic evidence for significant CAD (i.e. a luminal stenosis
of 50% or more) was found in 53 patients (62%), The overall sensitivity fo
r detection of CAD was 94%, specificity 78%, positive predictive value 88%
and negative predictive value 89%. In addition we calculated the diagnostic
value using partial or complete reversible perfusion defects instead of fi
xed or reversible perfusion defects; a lower sensitivity (64%) and a higher
specificity (97%) were found. For the detection of multivessel disease ins
tead of single or no vessel disease the sensitivity and specificity were bo
th 68%, The left anterior descending coronary artery, the right coronary ar
tery and the left circumflex artery showed a sensitivity of 74%, 89% and 44
% and a specificity of 70%, 64% and 88%, re-spectively.
Conclusion: This study demonstrates that Tc-99m tetrofosmin SPECT is quite
sensitive for the overall detection of CAD, and specific for the detection
of reversible perfusion defects.