New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

Three new sesquiterpene lactones (acetyltrifloculoside, 8.15-acetylsalonite nolide and 8-acelylsalonitenolide) and two known sesquiterpene lactones wer e isolated from a dichloromethane extract of the Portuguese liverwort Targi onia lorbeeriana. Their structures were established by spectroscopic method s (EI and D/CI mass spectroscopy. H-1 and C-13 NMR) and that of acetyltrifl oculoside was confirmed by X-ray crystallography. The three isolated guaian olide sesquiterpene lactones presented antifungal activity against Cladospo rium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans. (C) 199 9 Elsevier Science Ltd. All rights reserved.