Preparation, spectral properties and antimicrobial effects of new Cu(II) compounds with some bio-active ligands

The compounds [Cu(ac)(2)(Et(2)na)](2). Et(2)na . 2H(2)O (I), Cu(Clac)(2)(Et (2)na)(3) (II), Cu(Cl(2)ac)(2)(Et(2)na)(2). 2H(2)O (In), [Cu(ac)(2)mpc](2). 2CH(3)OH (IV), Cu(Clac)(2)(mpc) (V), Cu(Cl(2)ac)(2)(mpc)(2) (VI), Cu(Cl(3) ac)(2)(mpc)(2) (VII), Cu(pc). 5H(2)O (VIII), where ac = CH3COO-, Clac = ClC H2COO-, Cl(2)ac = Cl2CHCOO-, Cl(3)ac = Cl3CCOO-, Et(2)na = N,N-diethylnicot inamide, mpc methyl-3-pyridyl carbamate and pc = 2,6-pyridinedicarboxylate have been prepared and characterized by elemental analysis, IR, EPR and ele ctronic spectra. Their antimicrobial effects have been tested on various fu ngal strains. Significant morphological changes of Botrytic cinerea were ob served by the compounds V and VII. The highest antimicrobial effects were m anifested by compound IV. IC50 and MIC of that compound are 220 and 1000 mu g/ml against Rhizopus oryzae, 250 and 500 mu g/ml against Microsporum gyps eum, respectively. IR data suggest a unidentate coordination of carboxylate to Cu(II). Et(2)na and mpc were coordinated through the N atom of the hete rocyclic rings. EPR spectra suggest a dimeric structure of complexes I and IV and monomeric structure of complexes TI, III, V-VIII.