Sm. Heidemann et al., Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia, PROS LEUK E, 60(3), 1999, pp. 181-185
Citations number
21
Categorie Soggetti
Cell & Developmental Biology
Journal title
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Ibuprofen, a cyclooxygenase inhibitor, improves pulmonary and cardiovascula
r injury in endotoxemia, We studied the mechanism of the beneficial effects
of ibuprofen in relation to production of inflammatory mediators which inf
luence vascular tone in endotoxemia. Rats were randomly assigned to one of
three groups: (1) control, (2) endotoxemia alone; and (3) ibuprofen pretrea
tment and endotoxemia. Plasma and lung lavage concentrations of tumor necro
sis factor, thromboxane B-2 (TXB2), leukotriene (LT) C-4,D-4,E-4 and nitric
oxide (NO) were determined over a 2 h period. Pretreatment with ibuprofen
resulted in increased survival, and attenuation of pulmonary and cardiovasc
ular dysfunction when compared to the rats receiving endotoxin alone. The m
arked elevation in plasma TXB2 concentration in endotoxemic rats was preven
ted by pretreatment with ibuprofen. Similarly, pretreatment with ibuprofen
prevented the decrease in lung lavage NO levels in endotoxemic rats. The im
proved survival and cardiopulmonary protection in endotoxemic rats pretreat
ed with ibuprofen appears to be related to decreased thromboxane production
and preservation of endothelial production of nitric oxide.