Je. Heavner et al., Percutaneous epidural neuroplasty: Prospective evaluation of 0.9% NaCl versus 10% NaCl with or without hyaluronidase, REG ANES PA, 24(3), 1999, pp. 202-207
Background and Objectives. Percutaneous epidural neuroplasty (epidural neur
olysis, lysis of epidural adhesions) is an interventional pain management t
echnique that has emerged over approximately the last 10 years as part of a
multidisciplinary approach to treating radiculopathy with low back pain. L
n addition to local anesthetic and corticosteroid, hypertonic saline (10% N
aCl) and hyaluronidase are used for the technique. The objective of this st
udy was to determine if hypertonic saline or hyaluronidase influenced treat
ment outcomes. Methods. Eighty-three subjects with radiculopathy plus low b
ack pain were assigned to one of four epidural neuroplasty treatment groups
: (a) hypertonic saline plus hyaluronidase, (b) hypertonic saline, (b) isot
onic saline (0.9% NaCl), or (d) isotonic saline plus hyaluronidase. Subject
s in all treatment groups received epidural corticosteroid and local anesth
etic. Results. Twenty-four subjects did not complete the study. Most of the
other 59 subjects receiving any of the four treatments as part of their pa
in management obtained significant relief immediately after treatment. Visu
al analog scale (VAS) scores for the area of maximal pain (VAS(max); back o
r leg) were reduced in 25% or more of subjects in all treatment groups at a
ll post-treatment follow-up times (1, 3, 6, 9, and 12 months). A smaller fr
action of subjects treated with hypertonic saline or hyaluronidase and hype
rtonic saline required more additional treatments than did subjects receivi
ng the other treatments. Conclusions. Percutaneous epidural neuroplasty, as
part of an overall pain management strategy, reduces pain (sometimes for o
ver one year) in 25% or more of subjects with radiculopathy plus low back p
ain refractory to conventional therapies. The use of hypertonic saline may
reduce the number of patients that require additional treatments.