Prediction of the dermal penetration of polycyclic aromatic hydrocarbons (PAHs): A hierarchical QSAR approach

Attempts were made to develop hierarchical quantitative structure-activity relationship (QSAR) models for the dermal penetration of polycyclic aromati c hydrocarbons (PAHs) using four classes of theoretical structural paramete rs; viz., topostructural, topochemical, geometric, and quantum chemical des criptors; and physicochemical properties such as molecular weight (MW) and lipophilicity (log P - octanol/water). The results show that topostructural , topochemicaI, and geometric descriptors and molecular weight are equally effective in predicting the dermal penetration of PAHs. Quantum chemical pa rameters did not make any improvements in the predictive power of the QSAR models.