A one-pot synthesis and structure determination of 3-(1-phenyl-5-p-tolylpyrazol-3-yl)-2-p-tolylindole ethanol solvate

The Fischer indolization afforded the title compound C31H25N3. C2H5OH as th e major product in the reaction of 1,5-di(p-tolyl)pentane-1,3,5-trione with phenylhydrazine hydrochloride in ethanol. The structure assignment of this novel pyrazolylindole derivative is based on the data of elemental analysi s, IR, H-1 NMR, and C-13 NMR spectroscopy. The structure is also confirmed by means of X-ray crystallography. The molecule crystallizes in the orthorh ombic space group P 2(1)2(1)2(1), with a = 10.298(2), b = 14.984(5), c = 18 .133(3) A, Z = 8, V = 2798.0(12) A(3). The absolute structure has been dete rmined. The ethanol molecule forms intermolecular hydrogen bonds with the p yrazole and indole nitrogen atoms.