Synthesis of novel carbocyclic analogues of indolocarbazole natural products

Authors
Riley, DA Simpkins, NS Moffat, D
Citation
Da. Riley et al., Synthesis of novel carbocyclic analogues of indolocarbazole natural products, TETRAHEDR L, 40(20), 1999, pp. 3929-3932
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
20
Year of publication
1999
Pages
3929 - 3932
Database
ISI
SICI code
0040-4039(19990514)40:20<3929:SONCAO>2.0.ZU;2-J
Abstract
The synthesis of some cyclopentane-bridged indolocarbazoles, representing c arbocyclic analogues of the natural product K-252a, has been achieved by a concise, convergent route, and the ring expansion of one compound to a Stau rosporine-type derivative demonstrated. The products are potent inhibitors of protein kinase C (PKC). (C) 1999 Elsevier Science Ltd. All rights reserv ed.