Aryl H-phosphonates. 8. Simple and efficient method for the preparation ofnucleoside H-phosphonothioate monoesters

Authors
Kers, I Kers, A Stawinski, J Kraszewski, A
Citation
I. Kers et al., Aryl H-phosphonates. 8. Simple and efficient method for the preparation ofnucleoside H-phosphonothioate monoesters, TETRAHEDR L, 40(20), 1999, pp. 3945-3948
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
20
Year of publication
1999
Pages
3945 - 3948
Database
ISI
SICI code
0040-4039(19990514)40:20<3945:AH8SAE>2.0.ZU;2-G
Abstract
An efficient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters was developed. It consists of phosphonylation of suitably prote cted nucleosides with diphenyl H-phosphonate to produce nucleoside phenyl H -phosphonates, followed by their sulfhydrolysis with hydrogen sulfide. (C) 1999 Elsevier Science Ltd. All rights reserved.