A short procedure for the preparation of highly functionalized di- and tetrahydropyridines

Authors
Bennasar, ML Zulaica, E Juan, C Llauger, L Bosch, J
Citation
Ml. Bennasar et al., A short procedure for the preparation of highly functionalized di- and tetrahydropyridines, TETRAHEDR L, 40(20), 1999, pp. 3961-3964
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
20
Year of publication
1999
Pages
3961 - 3964
Database
ISI
SICI code
0040-4039(19990514)40:20<3961:ASPFTP>2.0.ZU;2-P
Abstract
The addition of a series of stabilized carbon nucleophiles to 3-acyl-1-alky lpyridinium salts, followed by acylation of the intermediate dihydropyridin es with trichloroacetic anhydride has been studied. The C-4 adducts resulti ng from the addition of alpha-(methylsulfanyl)ester enolates have been conv erted into synthetically useful 1,2.3,4-tetrahydropyridines. (C) 1999 Elsev ier Science Ltd. All rights reserved.