Ml. Bennasar et al., A short procedure for the preparation of highly functionalized di- and tetrahydropyridines, TETRAHEDR L, 40(20), 1999, pp. 3961-3964
The addition of a series of stabilized carbon nucleophiles to 3-acyl-1-alky
lpyridinium salts, followed by acylation of the intermediate dihydropyridin
es with trichloroacetic anhydride has been studied. The C-4 adducts resulti
ng from the addition of alpha-(methylsulfanyl)ester enolates have been conv
erted into synthetically useful 1,2.3,4-tetrahydropyridines. (C) 1999 Elsev
ier Science Ltd. All rights reserved.