Induction of resistance against Schistosoma mansoni infection by passive transfer of an IgG2a monoclonal antibody

Monoclonal antibodies can confer resistance to schistosome infections. This has led to identification of several protective antigens. An IgG2a monoclo nal antibody designated BRL4 mAb identified a 74-kDa antigen in antigenic e xtract of Schistosoma mansoni adult worms. The target antigen was localized in gut and tegument. In 3 passive transfer experiments, the BRL4 mAb confe rred 51.6, 41.9 and 53.8% protection levels into female Swiss mice. Histopa thological examination revealed a marked decrease in number, size. collagen and reticular fibers of the liver granulomas. Further experiments using pu rified 74-kDa-target antigen as a candidate vaccine will be performed. (C) 1999 Elsevier Science Ltd. All rights reserved.