Elimination of methoxyacetic acid and ethoxyacetic acid in rat

1. The pharmacokinetics of methoxyacetic acid (MAA) and ethoxyacetic acid ( EAA) have been determined in the male and female rat. following bolus intra venous administration at 100 mg/kg. The plasma-concentration data of MAA fi tted well to a one-compartment model, and the plasma-concentration data of EAA to a two-compartment model. 2. The elimination half-life of MAA estimated from plasma data was higher i n females (18.6 +/- 2.0 h) than in males (13.2 +/- 0.4 h). There was no dif ference in the elimination half-lives estimated from urine data. The appare nt volume of distribution was lower in the male than in the female rat esti mated from plasma data only, while ACC, total and non-renal clearances and the relative amount MAA excreted unchanged in urine was similar in the male and female rat. 3. Clearance of EAA is higher than of MAA, and this appears as a result of metabolic capacity. The elimination half-lives of EAA were similar in the m ale and female rat, 9.4 +/- 3.7 and 10.5 +/- 2.6 h respectively. AUC was hi gher in the female compared with the male rat. The fraction of EAA eliminat ed during the distribution phase was 44.0 +/- 15.4 and 41.0 +/- 17.4% in th e male and female rat respectively. The initial volume of distribution, the apparent volume of distribution, total and non-renal clearance are higher in the male compared with the female rat.