Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products

Authors
Zhou, B Zhang, JP Hu, ZL Tan, YX Qian, DH
Citation
B. Zhou et al., Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products, ACT PHAR SI, 20(5), 1999, pp. 449-451
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ACTA PHARMACOLOGICA SINICA
ISSN journal
02539756 → ACNP
Volume
20
Issue
5
Year of publication
1999
Pages
449 - 451
Database
ISI
SICI code
0253-9756(199905)20:5<449:R3IROI>2.0.ZU;2-W
Abstract
AIM: To study the effect of fibrin fibrinogen degradation products (FFDP) o n release of interleukin-l (IL-I) and interleukin-6 (IL-6) from mouse perit oneal macrophages, and the effect of a new selectively potent protein kinas e C inhibitor Ro 31-8220 (Ro). METHODS: IL-1 and 1L-6 activities were measu red by thymocyte proliferation assay and Bg cell proliferation methyl thiaz olyl tetrazolium (MTT) colorimetric method, respectively. RESULTS: Ro 0.01 -1 mu mol.L-1 obviously inhibited FFDP-induced release of IL-1 and IL-6 fro m mouse peritoneal macrophages. CONCLUSION: Ro exerted inhibitory effects o n FFDP-induced release of IL-1 and IL-6 in vitro.