Cutaneous granular cell neoplasms of nonneural origin: a study of 8 cases

We report six cases of benign fibrous histiocytoma, one case of dermatomyof ibroma, one case of cutaneous leiomyosarcoma with a granular cell component . Besides the clinical, histologic and immunohistochemical features of the primary lesion, these tumors do, not express S100 protein in contrast to th e classic granular cell tumor described by Abrikossoff. Such a component ha s no implication in prognosis, which remains related to the main lesion. Ig norance of this rare event can lead to misdiagnosis, requiring a total revi sion of the granular cell tumor entity.