Inhibition of human telomerase by PNA-cationic peptide conjugates

Authors
Harrison, JG Frier, C Laurant, R Dennis, R Raney, KD Balasubramanian, S
Citation
Jg. Harrison et al., Inhibition of human telomerase by PNA-cationic peptide conjugates, BIOORG MED, 9(9), 1999, pp. 1273-1278
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
9
Year of publication
1999
Pages
1273 - 1278
Database
ISI
SICI code
0960-894X(19990503)9:9<1273:IOHTBP>2.0.ZU;2-H
Abstract
The inhibition of human telomerase has been explored using peptide conjugat ed derivatives of a PNA pentamer directed at the RNA template of telomerase . It is demonstrated that the presence of cationic peptides at the N-termin us of the PNA results in enhanced inhibition of telomerase activity. Furthe rmore, inhibition depended on the specificity of PNA recognition, (C) 1999 Elsevier Science Ltd. All rights reserved.