Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists

Authors
Tao, B Huang, TL Sharma, TA Reynolds, IJ Donkor, IO
Citation
B. Tao et al., Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists, BIOORG MED, 9(9), 1999, pp. 1299-1304
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
9
Year of publication
1999
Pages
1299 - 1304
Database
ISI
SICI code
0960-894X(19990503)9:9<1299:NBABAN>2.0.ZU;2-X
Abstract
A series of novel bisbenzamidines and bisbenzimidazolines with different li nkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC,, values for these compounds ranged from 1.2 to >20 0 mu M. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pen tamidine analogues tested so far. (C) 1999 Elsevier Science Ltd. All rights reserved.