New technique for high-throughput synthesis

A new technique for high throughput solid phase synthesis using the centrif uge based liquid removal from readily available standard microtiterplates i s described. This technique eliminates the filtration step and is therefore applicable to simultaneous processing of an unlimited number of reaction c ompartments. Its application is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones. (C) 1999 Elsevier Science Ltd. All rights r eserved.