Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

Authors
Barn, DR Bom, A Cottney, J Caulfield, WL Morphy, JR
Citation
Dr. Barn et al., Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis, BIOORG MED, 9(9), 1999, pp. 1329-1334
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
9
Year of publication
1999
Pages
1329 - 1334
Database
ISI
SICI code
0960-894X(19990503)9:9<1329:SONAOT>2.0.ZU;2-4
Abstract
Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-IO. A novel acyclic derivative of SNC-8 0 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the delta-opioid receptor. (C) 199 9 Elsevier Science Ltd. All rights reserved.