Divergent changes in survival for histological types of non-small-cell lung cancer in the southeastern area of The Netherlands since 1975

We studied the incidence and survival rates for the histological subtypes o f non-smalt-cell lung cancer, using data from the Eindhoven Cancer Registry over the period 1975-94, The proportions with adenocarcinoma and large-cel l undifferentiated carcinoma increased from 11% to 21% and from 11% to 15%, respectively, while those with squamous cell carcinoma decreased from 78% to 62%. The increase in the proportion with adenocarcinoma was only found a mong men. Although the overall prognosis for patients with non-small-cell l ung cancer has remained unchanged, there have been divergent changes betwee n morphological subtypes. Relative 1- and 5-year survival rates for squamou s cell carcinoma have improved slightly from 48% to 51% and from 14% to 76% , respectively, because of an increase in the proportion with localized tum ours, while relative 1- and 5-year survival rates for adenocarcinoma have d ecreased from 59% to 45% and from 28% to 18%, respectively, because of a de crease in localized tumours. The proportion with localized tumours and the relative I-year survival for large-cell undifferentiated carcinoma (about 1 8% and 30% respectively) were markedly lower. The divergent trends could pa rtly be explained by changes in the histological classification of tumours, but changes in patterns of risk and biological behaviour of adenocarcinoma cannot be excluded.