Apoptosis and cancer

Apoptosis ol programmed cell death is a form of regulated cell death that r epresents an important biological principle in tissue development and homeo stasis. Its regulation appears to be perturbed in several major diseases, i ncluding cancel: The control of cell death events is extremely complex at t he genetic and biochemical levels. It has been suggested that genes or fact ors that suppress apoptosis are essential components of carcinogenesis. The complete mechanisms implicated in apoptosis remains an issue for a future investigation Details of how the death pathway itself is initiated, will pr ovide a firm basis for the development of agents capable of eliciting the p rocess in chemoresistant tumours.