The global importance of food safety is not fully appreciated by many publi
c health authorities despite a constant increase in the prevalence of foodb
orne illness. Numerous devastating outbreaks of salmonellosis, cholera, ent
erohaemorrhagic Escherichia coli infections, hepatitis A and other diseases
have occurred in both industrialized and developing countries. In addition
, many of the re-emerging or newly recognized pathogens are foodborne or ha
ve the potential of being transmitted by food and/or drinking water. More f
oodborne pathogens can be expected because of changing production methods,
processes, practices and habits. During the early 21st century, foodborne d
iseases can be expected to increase, especially in developing countries, in
part because of environmental and demographic changes. These vary from cli
matic changes, changes in microbial and other ecological systems, to decrea
sing freshwater supplies. However, an even greater challenge to food safety
will come from changes resulting directly in degradation of sanitation and
the immediate human environment. These include the increased age of human
populations, unplanned urbanization and migration and mass production of fo
od due to population growth and changed food habits. Mass tourism and the h
uge international trade in food and feed is causing food and feedborne path
ogens to spread transnationally. As new toxic agents are identified and new
toxic effects recognized, the health and trade consequences of toxic chemi
cals in food will also have global implications. Meeting the huge challenge
of food safety in the 21st century will require the application of new met
hods to identify, monitor and assess foodborne hazards. Both traditional an
d new technologies for assuring food safety should be improved and fully ex
ploited. This needs to be done through legislative measures where suitable,
but with much greater reliance on voluntary compliance and education of co
nsumers and professional food handlers. This will be an important task for
the primary health care system aiming at "health for all".